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J.MorrowC

Molecular Genetics and Metabolism

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

Chem Mater 29:371388

In implantable xenograft models (LDHB KD A549 and H838), the SLC7A11 inhibitor Erastin (administrated at 30mg/kg) significantly and consistently suppressed the growth of LDHB KD tumors, despite marginal effects on control A549 and H838 tumors ( Supplementary Figure 9a )